Since prehistoric times opiates have been used for medicinal purposes for diverse conditions including depression, psychosis, pain, addiction and other psychiatric conditions. IntroductionĮndorphins and endorphin agonists play a crucial role in the neural modulation of mood, anxiety, pain and addiction. Recent studies have also elucidated a crucial mechanism of treating depression- enhancing prefrontal cortex influence and dampening limbic and sub cortical influences- similar to the neurobiological actions of endorphin agonists.ĭespite much publicity of an alleged causal association between prescription pain medications and an epidemic of overdose deaths, no scientific evidence exists to support a causal link between prescription opiates and the overdose deaths.ĭespite concerns of addiction and misuse potential further research to study endorphin agonists for diverse psychiatric disorders seems warranted. Historical, experimental and clinical data strongly support the potential benefits of opiates for severe depression, addictive disorders, pain and psychosis. Endorphins and endorphin agonists play a crucial role in the neural modulation of mood, anxiety, pain and addiction.
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